Figure 7
From: Generation of pluripotent stem cells without the use of genetic material
Schematic illustration of somatic cell reprogramming to iPSCs and progenitor or adult stem cells. Somatic cells can be reprogrammed to iPSCs using viral or non-viral introduction of exogenous TFs or protein transfection. Small molecules can either substitute for certain TFs and/or improve reprogramming efficiency by epigenetic modifications or signaling pathway regulation. The abbreviations of the small molecules are shown in Table 2.
