Figure 1 | Laboratory Investigation

Figure 1

From: Treatment with CA-074Me, a Cathepsin B inhibitor, reduces lung interstitial inflammation and fibrosis in a rat model of polymyositis

Figure 1

HE and Masson’s trichrome staining analyses of inflammation and fibrosis in lung tissues from patients with PM/DM (10 × 40). (a ,c)=Healthy group (n=5); (b, d)=Patient group (n=6). In PM/DM patients, the inflammatory score was significantly higher (a). The grading of histological lesion (the fibrosis score) in lung tissues in healthy controls was significantly less than that in the patients group (b). The collagen area rate in lung tissues increased in the patients group in comparison with healthy group with significant difference (c). There was no infiltration of inflammatory cells in lung tissues of healthy controls (d-A), but the infiltration of inflammatory cells, widened alveolar septa, and pulmonary interstitial fibrosis in lung tissues were found in PM/DM patients (d-B). The collagen area and degree of fibrosis in lung tissues in healthy controls (d-C) was less observed than that in the patients group (d-D). Data are expressed as means±s.d. and compared by Student t-test. *P<0.05 in comparison with Healthy group.

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