Figure 1 | Laboratory Investigation

Figure 1

From: Inactivation of Notch signaling reverses the Th17/Treg imbalance in cells from patients with immune thrombocytopenia

Figure 1

Inactivation of Notch signaling by DAPT. PBMCs from ITP patients and controls were treated with DAPT ranging from 2.5 to 20 μM for 72 h in vitro. Cells were harvested for quantitative real-time RT-PCR to analyze the change in mRNA expression of Notch1 (a, b), Hes1 (c, d), and Hey1 (e, f) in each group. Data shown were relative to DMSO group in ITP patients or healthy controls. Data represent the median (range) from three separate experiments and *P<0.05.

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