Figure 5 | Laboratory Investigation

Figure 5

From: Inactivation of Notch signaling reverses the Th17/Treg imbalance in cells from patients with immune thrombocytopenia

Figure 5

Inhibition of Notch signaling by DAPT significantly downregulated Th17 cell-associated cytokine IL-17 but IL-21 or Treg-associated cytokine IL-10 secretion. After 3 days of DAPT treatment, culture supernatant of each group was harvested for ELISA. The comparison of IL-17 (a), IL-21 (b), and IL-10 (c) was made between ITP patients and healthy controls without DAPT treatment. IL-17 (d), IL-21 (e), and IL-10 (f) in treated PBMCs from ITP patients and healthy controls, respectively. Data are shown as median (range). *P<0.05, **P<0.01.

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