Table 2 Physiologic conditions at the beginning and end of ventilation

	Control without bleomycin wild type	Control with bleomycin wild type	V_T 6 ml/kg with bleomycin wild type	V_T 30 ml/kg with bleomycin wild type	V_T 30 ml/kg with bleomycin Src^+/−	V_T 30 ml/kg with bleomycin wild type, PP2
PH	7.41±0.04	7.39±0.03	7.36±0.04	7.34±0.05	7.38±0.06	7.36±0.07
PaO₂ (mm Hg)	97.8±0.3	96.2±0.1	85.3±0.5*	76.9±1.2*^†	86.6±1.1*	84.2±1.4*
PaCO₂ (mm Hg)	39.1±0.2	39.4±0.2	41.2±0.3	36.5±0.9	36.8±1.5	36.7±1.6
MAP (mm Hg)
Start	85±0.9	83±0.7	83.2±1.1	82.3±1.4	83.0±1.4	82.6±1.8
End	83±0.6	81±0.3	79.4±1.5	73.6±4.8*^†	78.9±2.0*	76.2±4.5*
PIP, mm Hg
Start			9.9±1.0	23.6±1.3	23.3±1.7	23.5±1.2
End			11.7±0.9	28.3±2.1	26.9±1.8	27.2±2.9

Abbreviations: MAP, mean arterial pressure; PIP, peak inspiratory pressure; Src^+/−, Src-deficient mice; V_T, tidal volume.
The physiological data of the control groups were similar during the experiment and were used as the beginning data of ventilation.
At the end of the study period, arterial blood gases and MAP were obtained from the nonventilated control mice and mice subjected to V_T at 6 ml/kg or at 30 ml/kg for 5 h (n=10 per group). The normovolemic statuses of mice were maintained by monitoring mean artery pressure. Data are presented as mean±s.d.
*P<0.05 vs the nonventilated control mice with bleomycin pretreatment.
^†P<0.05 vs all other groups.

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