Figure 6 | Laboratory Investigation

Figure 6

From: LL-37 secreted by epithelium promotes fibroblast collagen production: a potential mechanism of small airway remodeling in chronic obstructive pulmonary disease

Figure 6

CSE-induced epithelial secretion of LL-37 upregulated fibroblast collagen production. (a) 16HBE and HFL-1 cells were co-cultured in six-well plates without direct contact. After exposure to CSE for 48 h, total collagen production was elevated in a dose-dependent manner. LL-37 antibody significantly abolished collagen production, while anti-IgG had no effect on collagen production. *P<0.01, compared with the control group. #P<0.01, compared with 6% CSE group. (b) CSE exposure for 48 h has no significant effect on collagen production in HFL-1 cells.

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