Figure 5 | Laboratory Investigation

Figure 5

From: Micheliolide, a new sesquiterpene lactone that inhibits intestinal inflammation and colitis-associated cancer

Figure 5

DMAPT and DMAMCL decrease colitis severity in a DSS-induced colitis model. WT mice were subjected to 5 days of DMAPT or DMAMCL pre-treatment followed by 7 days of simultaneous addition of DMAPT and DMAMCL and DSS. Spleen weights (a) and colon lengths (b) were measured. *P<0.05 compared with mice treated with DSS only. (c) Representative H&E-stained colons. Scale bar=100 μm. (d) Histological scores determined from H&E-stained colons. (e) Colonic MPO activity was quantified in the distal colon. *P<0.05 compared with mice treated with DSS only.

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