Figure 8
DMAPT and DMAMCL reduce colonic tumorigenesis in a mouse model of CAC. Mice were IP injected with AOM (10 mg/kg body weight) and maintained for 7 days, then subjected to two-cycle DSS treatment (7 days of 2.5% DSS and 14 days of H2O). (a) Representative colons obtained at the end of the CAC protocol. (b) Number of tumors per mouse. (c and d) Tumor size (c) was determined using a dissecting microscope, and total tumor area per mouse (d) was calculated. (e) Representative H&E-stained colonic tumors at the end of the CAC protocol. Scale bars=100 μm. (f) Colonic MPO activity was quantified in the distal colon. *P<0.05 compared with mice treated with AOM/DSS only.
