Figure 9 | Laboratory Investigation

Figure 9

From: Micheliolide, a new sesquiterpene lactone that inhibits intestinal inflammation and colitis-associated cancer

Figure 9

DMAPT and DMAMCL inhibit the AOM/DSS-induced increase in pro-inflammatory markers. (a) Colonic mRNA levels of IL-1β, TNFα, and IL-6 were quantified by qRT-PCR and normalized to mRNA levels for the ribosomal protein 36B4. *P<0.05 compared with mice treated with AOM/DSS only. (b) Cyclin D1, PCNA, and β-actin proteins in mice treated with AOM/DSS and DMAPT, DMAMCL, or water only (control) were analyzed by western blotting. Bar graph represents the densitometric quantification of Cyclin D1 and PCNA normalized to β-actin. *P<0.05 compared with mice treated with AOM/DSS only.

Back to article page