Figure 6
From: The microbiota regulates susceptibility to Fas-mediated acute hepatic injury
The Fas death receptor is critical for ConA liver injury and direct Fas triggering results in greater liver injury in JAX mice than in TAC mice. (a) Littermate homozygous Fas-deficient (−/−), heterozygous (+/−), and homozygous wild-type (+/+) mice were ConA challenged and liver and blood taken at 24 h. Data are aggregated from results from two litters. (b) BALB/c JAX mice and BALB/c TAC mice were injected with anti-Fas (Jo-2) at the indicated doses. Blood was harvested at 10 h (left) and 24 h (right) and ALT measured. (c) Histopathological scoring of TAC livers and JAX livers 6 h after Jo-2 injection (0.1 μg/g) shows more severe pathology in JAX livers. Arrows indicate pyknotic nuclei, consistent with apoptosis. Scale bar=100 μm. *P<0.05.
