Figure 3 | Laboratory Investigation

Figure 3

From: Merkel cell carcinoma expresses vasculogenic mimicry: demonstration in patients and experimental manipulation in xenografts

Figure 3

Vasculogenic mimicry in Merkel cell carcinoma xenografts after chemotherapy. MKL-1 tumors treated with vehicle, carboplatin, and etoposide stained for CD31 (upper panels; original magnification, × 100) and laminin (Lam; middle panels; original magnification, × 100); rectangular regions are representative fields enlarged for clarity (original magnification, × 1000). Note the marked and widespread increase in laminin+ networks after chemotherapy. A similar picture is observed in WaGa-derived tumors, although less diffuse (data not shown). A statistically significant increase in laminin immunoreactivity after carboplatin is observed in both cell lines, and after etoposide in MKL-1-derived tumors (graphs, lower panels). CD31, platelet endothelial cell adhesion molecule 1; LAM, laminin.

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