Table 1 Cancer-related genes expressed in PBMo-derived macrophages stimulated with TECM

From: GDF15 derived from both tumor-associated macrophages and esophageal squamous cell carcinomas contributes to tumor progression via Akt and Erk pathways

Accession number

Gene title

Symbol

Log2 ratioa

   

TE-8CMb

TE-9CMb

TE-15CMb

Upregulated genes (log2 ratio a >2)

 NM_000575

Interleukin 6

IL6

7.20

5.99

5.41

 NM_000584

Interleukin 8

IL8

5.06

5.18

4.89

 NM_002981

Chemokine (C-C motif) ligand 1

CCL1

7.03

6.82

5.90

 NM_001511

Chemokine (C-X-C motif) ligand 1

CXCL1

5.48

5.57

5.36

 NM_002421

Matrix metallopeptidase 1, transcript variant 1

MMP1

5.45

4.71

5.27

 NM_002424

Matrix metallopeptidase 8

MMP8

5.15

6.10

6.20

 NM_004864

Growth differentiation factor 15

GDF15

4.33

3.75

3.96

Downregulated genes (log2 ratio a <−2)

 NM_002989

Chemokine (C-C motif) ligand 21

CCL21

−3.58

−4.26

−5.28

 NM_006419

Chemokine (C-X-C motif) ligand 13

CXCL13

−2.48

−2.66

−2.32

 NM_001719

Bone morphogenetic protein 7

BMP7

−3.07

−3.23

−3.28

 NM_000618

Insulin-like growth factor 1, transcript variant 4

IGF1

−4.00

−7.51

−6.88

 NM_004464

Fibroblast growth factor 5, transcript variant 1

FGF5

−3.99

−4.17

−4.23

  1. aLog2 ratio: differential expression is reported as the log2 ratio of two spot values in comparison with PBMo-derived macrophages stimulated without TECM. A spot with equal signals on each cDNA microarray have a log2 ratio of zero.
  2. bTECM: conditioned media of TE series ESCC cell lines.
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