Figure 6 | Laboratory Investigation

Figure 6

From: Osteopontin depletion decreases inflammation and gastric epithelial proliferation during Helicobacter pylori infection in mice

Figure 6

Effect of OPN on the activation of MAPK pathway in gastric cancer cells and mouse gastric tissues during HP infection. (a) MTT assays for cell viability at 24 h after IL-1β or TNF-α treatment in OPN KD gastric cancer cells. MAPK-related protein expression in OPN KD AGS cells treated with (b) IL-1β and (c) TNF-α at the respective time points. Expression levels of MAPK-related proteins in OPN KD S1M cell treated with (d) IL-1β and (e) TNF-α. (f) MAPK-related protein expression in OPN KO mouse gastric tissues infected with HP. Results are presented as mean±s.e.m. (n=2). *P<0.05 versus shControl-transfected cell. p-Akt, phosphorylated Akt; t-Akt, total Akt; p-ERK, phosphorylated ERK; t-ERK, total ERK.

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