Figure 2
From: MicroRNA-17-5p activates hepatic stellate cells through targeting of Smad7
miR-17-5p expression in CCl4-treated hepatic fibrotic and control tissues. (a) Hepatic fibrotic and control tissues were detected by hematoxylin and eosin (H&E) staining ( × 100) and Masson staining ( × 100), respectively. Black arrows indicate hepatic steatosis, necrosis and formation of regenerative nodules. (b) The α-SMA level was analyzed using immunohistochemistry in CCl4-treated hepatic fibrotic and control tissues ( × 100). (c) Immunoexpression of α-SMA in hepatic fibrotic and control tissues. (d) Increased miR-17-5p expression in hepatic fibrotic tissues, compared with control tissues. Each value represents the mean±s.d. of three experiments. *P<0.05, compared with the control.
