Figure 2 | Laboratory Investigation

Figure 2

From: Identification, by systematic RNA sequencing, of novel candidate biomarkers and therapeutic targets in human soft tissue tumors

Figure 2

Interaction networks involving significantly upregulated genes in our (a) angiosarcoma, (b) epithelioid sarcoma, (c) Ewing’s sarcoma, (d) fibromatosis, (e) schwannoma, and (f) synovial sarcoma datasets. Red nodes are upregulated genes. Blue nodes are significantly enriched upstream activating transcriptional regulators in each of our sarcoma datasets; bold indicates transcription factors found to be significant in multiple sarcoma datasets. Red and blue striped nodes are identified upstream transcriptional regulators that were also significantly upregulated in the sarcoma dataset. Green nodes are miRNAs predicted to target key upregulated genes and/or transcriptional regulators that were significantly downregulated in sarcoma; bold indicates miRNAs predicted to target multiple upregulated genes in the sarcoma gene set. Gray nodes are compounds/agonists that effect the upregulated genes in this network. Orange nodes are key biologic and disease processes associated with the total set of upregulated genes for each sarcoma subtype.

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