Table 1 Top 10 uniquely upregulated genes in our sarcoma samples (genes in bold have not been previously associated with sarcoma; full gene lists and mean expression values are available in Supplementary Tables 1–6)

From: Identification, by systematic RNA sequencing, of novel candidate biomarkers and therapeutic targets in human soft tissue tumors

Sarcoma

Gene symbol

Ratio

Angiosarcoma

D21S2088E

4566

 

CCL1

974

 

HTN3

794

 

GPR182

419

 

MADCAM1

320

 

FLT4

252

 

SCGB3A1

238

 

NTS

76

 

MMP12

61

 

CTLA4

43

Epithelioid sarcoma

CST5

3467

 

ARHGAP36

1822

 

CDH10

1642

 

TMEM215

598

 

IGSF1

348

 

ZCCHC12

288

 

CST2

211

 

GAL3ST3

189

 

UNC5D

181

 

FOXL2NB

149

Ewing’s sarcoma

PCGEM1

12063

 

SLC17A8

4868

 

SCNN1G

1037

 

C6orf15

578

 

PGLYRP2

554

 

CALCA

546

 

C1QL2

454

 

LIPI

275

 

MAPT-AS1

258

 

NKX2-2

229

Fibromatosis

SERPINB11

981

 

LAMP5

76

 

ADAM12

52

 

POSTN

43

 

ADAMTS12

40

 

XPNPEP2

35

 

PLA2G2A

35

 

F2RL1

30

 

ZNF469

23

 

HMCN1

23

Schwannoma

GJB6

2026

 

GFAP

1124

 

GAP43

340

 

ANGPTL7

210

 

SOX10

205

 

GRIA4

174

 

SERPINA5

134

 

ITGB8

130

 

S100B

128

 

FABP7

121

Synovial sarcoma

C5orf58

122

 

SPATA22

113

 

ZIC1

96

 

FGF19

39

 

GPR126

31

 

ZIC4

29

 

FAM163B

29

 

GFRA2

22

 

DLX6-AS1

20

 

HOXC11

19