Figure 6 | Laboratory Investigation

Figure 6

From: Vascular endothelial growth factor receptor-3 is a novel target to improve net ultrafiltration in methylglyoxal-induced peritoneal injury

Figure 6

Analyses of peritoneal functions. Peritoneal equilibration test with a 7.5% icodextrin peritoneal dialysis fluid can identify the upregulation and suppression of lymphangiogenesis. Peritoneal dialysis fluid containing 7.5% icodextrin (2000 μl) was intraperitoneally injected into control, Adeno-Lac Z, or Adeno-sVEGFR-3-Ig mice. Drained dialysate was collected 4 h after administration. (a) There was a difference in effluent volume between groups as detected by the 7.5% icodextrin peritoneal equilibration test, indicating that the 7.5% icodextrin peritoneal equilibration test can identify the suppression of lymphangiogenesis. (b) Amylase levels in the effluent were significantly increased on day 22; however, there was no difference between the groups on days 22 and 50. (each group, n=6). ICO PET, icodextrin peritoneal equilibration test; Lac Z, treatment with Adeno-LacZ; NS, not significant; R3-Ig, treatment with Adeno-sVEGFR-3-Ig; sVEGFR-3, soluble vascular endothelial growth factor receptor-3.

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