Figure 6
From: Inhibition of dipeptidyl peptidase IV protects tacrolimus-induced kidney injury
Plasma and renal DPP IV activity and levels of the plasma glucagon-like peptide-1 (GLP-1), neuropeptide Y (NPY), and stromal cell-derived factor-1 (SDF-1) in experimental animals. (a and b) DPP IV activity is evaluated in the plasma and renal cortex of experimental animals. DPP IV activity is suppressed significantly by MK0626 (M). (c) The level of bioactive GLP-1 is remarkably higher in the MK0626 and tacrolimus (TAC) groups. (d and e) The other DPP IV substrates, NPY, and SDF-1 are also evaluated. The plasma NPY and SDF-1 levels are not different among the experimental groups. n=8 per group. #P<0.05 vs VH; $P<0.05 vs TAC; *P<0.05 vs TAC+M10.
