Table 1 The effect of MK0626 on TAC-induced renal dysfunction

	VH (n=8)	VH+M10 (n=8)	VH+M20 (n=8)	TAC (n=8)	TAC+M10 (n=8)	TAC+M20 (n=8)
BW (g)	268±5	270±3	270±4	279±6	273±3	269±4
UV (ml/day)	16±3	15±1	17±3	20±5	22±3	24±6
Water intake (ml/day)	23±4	19±2	21±3	28±6	26±3	30±7
SBP (mm Hg)	131±1	128±1	134±1	132±2	133±1	132±3
Scr (mg/dl)	0.34±0.03	0.35±0.01	0.30±0.03	0.58±0.05^a–c	0.45±0.01^a–d	0.46±0.02^a–d
BUN (mg/dl)	14±2	12±0.4	12±2	35±4^a–c	24±1^a–d	24±2^a–d
ClCr (mL/min/100g)	0.79±0.07	0.82±0.03	0.87±0.08	0.45±0.04^a–c	0.56±0.03^a–d	0.56±0.03^a–d
KIM-1 (%)	0.62±0.14	0.63±0.09	0.63±0.05	7.42±0.69^a–c	4.74±0.84^a–d	2.34±0.40 ^a–e
NGAL (%)	0.01±0.01	0.03±0.09	0.03±0.01	0.13±0.03^a–c	0.05±0.02^a–d	0.04±0.01^a–d
TAC level (ng/ml)	—	—	—	7.5±0.9	7.5±0.7	7.9±0.4

BUN, blood urea nitrogen; BW, body weight; ClCr, creatinine clearance; M10 and M20, 10 and 20 mg/kg of MK0626; SBP, systolic blood pressure; Scr, serum creatinine; TAC, tacrolimus; UV, urine volume; VH, vehicle. TAC level, trough blood level of TAC. Values are means±s.e. ^aP<0.05 vs VH, ^bP<0.05 vs VH + M10, ^cP<0.05 vs VH + M20, ^dP<0.05 vs TAC, ^eP<0.05 vs TAC+M10.

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