Figure 1

Weekly glucose monitoring. Glucose was measured weekly throughout the experiment to ensure the animals were diabetic. (mean and s.e.m. are plotted, *indicates P<0.001 for WT vs WT+DM, WT vs RAGE KO+DM, RAGE KO vs WT+DM, and RAGE KO vs RAGE KO+DM, ^indicates P<0.001 for WT DM vs RAGE KO+DM n=15). KO, knockout; RAGE, receptor for advanced glycation end products; WT, wild type; WT+DM, wild-type mice with diabetes.