Figure 2 | Laboratory Investigation

Figure 2

From: The receptor for advanced glycation end products impairs collateral formation in both diabetic and non-diabetic mice

Figure 2

Streptozotocin (STZ)-induced diabetes increases CML levels in blood and muscle tissue. Blood and muscle tissue were collected from the mice at the end of the study. An ELISA was used to assess CML levels in the blood serum (a) and muscle lysates (b). CML was increased in the diabetic groups of each genotype with no differences in overall levels between the genotypes. Mean and s.e.m. are plotted and *indicates P<0.05 and **indicates P<0.01 (n=8 for blood serum and n=6 for tissue lysate). CML, Nɛ-(carboxymethyl) lysine; KO, knockout; RAGE, receptor for advanced glycation end products; WT, wild type; WT+DM, wild-type mice with diabetes.

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