Figure 3
Diabetes impairs perfusion in WT mice but not in RAGE KO mice. Ischemia was induced in mice using the HLI procedure in either healthy or STZ-treated diabetic mice (DM). LPDI was used to noninvasively measure the reperfusion of the limb. (a) The perfusion ratio between the ischemic and non-ischemic leg on post-op day 21 shows impaired perfusion in WT+DM but not in RAGE KO mice. Mean and s.e.m. are plotted, *indicates P<0.05 vs WT, **indicates P<0.001 vs WT, and #indicates P<0.001 vs WT+DM (n=4–12). (b) Representative LDPI images of (a) WT, (b) RAGE KO, (c) WT+DM and (d) RAGE KO+DM. IL, ischemic leg; KO, knockout; NIL, non-ischemic leg; RAGE, receptor for advanced glycation end products; WT, wild type; WT+DM, wild-type mice with diabetes.
