Figure 4 | Laboratory Investigation

Figure 4

From: The receptor for advanced glycation end products impairs collateral formation in both diabetic and non-diabetic mice

Figure 4

Diabetic wild-type mice have decreased endothelial positive vessels. Histology slides of the hindlimbs were stained for smooth-muscle α-actin or with lectin and the number of vessels with smooth muscle cells or endothelial cells was quantified. α-Actin-positive microvessels were not different between the groups. (a) Lectin-positive vessels were significantly lower in the WT+DM group vs all the other groups. Additionally, WT was significantly different than RAGE KO+DM. (b) Representative images of each group are shown where red is lectin. Mean and s.e.m. are plotted, *indicates P<0.05. **indicates P<0.01 and ***indicates P<0.001. (n=6). KO, knockout; RAGE, receptor for advanced glycation end products; WT, wild type; WT+DM, wild-type mice with diabetes.

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