Figure 1 | Laboratory Investigation

Figure 1

From: Maresin1 stimulates alveolar fluid clearance through the alveolar epithelial sodium channel Na,K-ATPase via the ALX/PI3K/Nedd4-2 pathway

Figure 1

MaR1 protected lung tissues in LPS-induced ALI. MaR1(200ng/kg) was administered to Sprague–Dawley rats 8 h after LPS (14 mg/kg) stimulation through caudal vein or via alveolar instillation, ventilating for 60 min, and the effect of MaR1 was assessed (a) by histology in H&E-stained sections (original magnification × 400). Lung injury scores (b) were recorded from 0 (no damage) to 16 (maximum damage) according to the criteria described in ‘Materials and Methods’ section. Data are presented as mean±s.e.m. n=8. MaR1 (i.v.), intravenous. MaR1 (instill), alveolar instillation. The control group, equivalent volume of saline. **P<0.01 versus control group; ##P<0.01 versus LPS group.

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