Figure 3 | Laboratory Investigation

Figure 3

From: Maresin1 stimulates alveolar fluid clearance through the alveolar epithelial sodium channel Na,K-ATPase via the ALX/PI3K/Nedd4-2 pathway

Figure 3

MaR1-upregulated AFC in LPS-induced ALI in vivo. MaR1(200 ng/kg) was administered to Sprague–Dawley rats 8 h after LPS (14 mg/kg) stimulation through caudal vein or via alveolar instillation, ventilating for 60 min. Dose dependency of LPS-regulated AFC (a). MaR1-upregulated AFC (b). ENaC inhibitor experiments (c). Data are presented as mean±s.e.m. n=8. MaR1 (i.v.), intravenous. MaR1 (instill), alveolar instillation. The control group, equivalent volume of saline. *P<0.05 versus control group, **P<0.01 versuscontrol group; #P<0.05 versusLPS group, ##P<0.01 versus LPS group.

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