Figure 5 | Laboratory Investigation

Figure 5

From: Reversal of maladaptive fibrosis and compromised ventricular function in the pressure overloaded heart by a caveolin-1 surrogate peptide

Figure 5

CSD inhibits increases in integrin levels and NTK activation. Mice were treated as described in the ‘Materials and Methods’ section. For Sham control, samples from 6 weeks after surgery were used. LV tissue was extracted with RIPA buffer and the resulting soluble fraction used in western blotting experiments using antibodies against β1-integrin, β3-integrin, phospho-Pyk2-Y402, phospho-Src-Y416, and GAPDH (loading control). A representative Western blot is shown in (a). Densitometric quantification of data from three independent experiments is (b) β1-integrin, (c) β3-integrin upper band, (d) β3-integrin both bands, (e) pPyk2, and (f) pSrc. **P<0.01, TAC vs Sham; ^P<0.05, TAC+CSD vs TAC+vehicle, ^^P<0.01 TAC+CSD vs TAC+vehicle.

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