Figure 2
From: High-pressure carbon monoxide preserves rat kidney grafts from apoptosis and inflammation
Recipient survival rates and percent carboxyhemoglobin (CO-Hb). Recipient survival rates were assessed by following animals for 100 days after transplantation. (a) An orthotopic KTx was performed after preserving a rat kidney for 24 h using a chamber filled with a mixed gas of CO (PCO=4000 hPa) and O2 (PO2=3000 hPa; n=4), CO (PCO=2000 hPa) and O2 (PO2=1500 hPa; n=14), or room air (1000 hPa; n=5). (b) No significant differences were observed among the control (n=10), UW (n=14), CO (PCO=2000 hPa+PO2=1500 hPa, n=13), and N2 (PN2=2000 hPa+PO2=1500 hPa, n=9) groups. (c) Percent CO-Hb in the blood of naive Lewis rats and recipients with CO-treated grafts at 3 and 24 h after kidney transplantation (n=3/group). Fisher's LSD test, *P<0.05.
