Figure 9 | Laboratory Investigation

Figure 9

From: DA-1229, a dipeptidyl peptidase IV inhibitor, protects against renal injury by preventing podocyte damage in an animal model of progressive renal injury

Figure 9

Effects of DA-1229 on urinary protein and albumin excretion in the adriamycin-induced nephrotoxicity model. (a, b) Effects of DA-1229 on glomerulosclerosis and tubulointerstitial fibrosis (*P<0.05, ***P<0.001 vs adriamycin group; ###P<0.001 vs adriamycin group at 3 weeks). (c, d) Effects of DA-1229 on proteinuria and albuminuria in the preventive model of adriamycin-induced nephrotoxicity. (e, f) Effects of DA-1229 on proteinuria and albuminuria in the therapeutic model of adriamycin-induced nephrotoxicity. (g) Representative western blot showing the effects of DA-1229 on type I collagen and TGF-β1 expression in renal cortical tissue. TGF-β1, transforming growth factor 1. For c–f, Student’s t-test and the paired t-test were performed to compare two different groups at the same time point and responses within a single group at different time points, respectively. Values are expressed as means±s.e.m. Statistical analysis was performed between groups at the same time points. ***P<0.001 vs adriamycin (ADX) group at 0 week; ##P<0.01, ###P<0.001 vs adriamycin (ADX) group.

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