Figure 4
From: Modeling fibrosis using fibroblasts isolated from scarred rat vocal folds
Analysis of the scar VFF transcriptome. (a) Gene ontology-based enrichment analysis of DE genes in scar, compared with naïve, VFFs at P1. Enriched ontology terms are depicted as nodes; highly similar terms are connected by edges. Cellular component terms are green; molecular function terms are red; biological process terms are blue. Node color intensity corresponds to the Z-score associated with term enrichment. Node and label font size are proportional to the generality of the term in the underlying ontology. (b) Heat maps showing mean-centered log2-expression data for DE genes associated with the response to wounding, extracellular matrix, and cell division ontology terms. DE genes are ranked by log2 fold change (scar normalized to naïve) along the vertical axis. This experiment was performed with n=3 biological replicates in the naïve condition and n=4 biological replicates in the scar condition.
