Figure 6
From: Modeling fibrosis using fibroblasts isolated from scarred rat vocal folds
Effect of growth factor stimulation on scar-related transcriptional activity. Exogenous HGF stimulation downregulated Col1a1 (a) and Acta2 (b) transcription in scar VFFs at P1 in a dose-dependent manner, whereas exogenous TGF-β3 stimulation upregulated Acta2 transcription only (b). Data are presented as mean fold change±s.e.m. vs the untreated control (Ctl) condition and are log2-transformed to best represent bidirectional stimulation effects. All experiments were performed with n=4 biological replicates per condition. *P<0.05.
