Figure 2

2D-FLASH MRI (self-gated) of Aspergillus fumigatus-infected mouse lungs. (a) Representative coronal 2D-FLASH images of the lungs after instillation with saline (control, top row) or A. fumigatus FGSC A1258 (infection, bottom row). Dashed line depicts a manually defined ROI. (b, c) Graphs representing the normalized signal intensity and total lung volume quantified from the 2D-FLASH lung images of mice instilled with saline or A. fumigatus spores (ASFU 1731 or FGSC A1258 strain). Error bars represent s.d. of multiple mice (saline: n=5, ASFU 1731: n=7–10, FGSC A1258: n=7–8). ***P<0.001; ****P<0.0001.