Figure 3 | Laboratory Investigation

Figure 3

From: Longitudinal, in vivo assessment of invasive pulmonary aspergillosis in mice by computed tomography and magnetic resonance imaging

Figure 3

3D-FLASH MRI (self-gated) of the lungs after infection with Aspergillus fumigatus. (a) Representative coronal 3D-FLASH MR images of the lungs after intranasal instillation with saline (control, top row) or A. fumigatus FGSC A1258 (infection, bottom row). Dashed line depicts a manually defined region of interest (ROI) used to quantify disease progression. (b) Graph representing the cumulative image score derived from the 3D-FLASH images of mice instilled with saline or A. fumigatus spores (ASFU 1731 or FGSC A1258 strain). (c–e) Graphs representing the normalized signal intensity, lung tissue volume and total lung volume quantified from the 3D-FLASH lung images. Error bars represent s.d. of multiple mice (saline: n=3–4, ASFU 1731: n=4, FGSC A1258: n=4–8). *P<0.05; **P<0.01; ***P<0.001; ****P<0.0001.

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