Figure 4 | Laboratory Investigation

Figure 4

From: Longitudinal, in vivo assessment of invasive pulmonary aspergillosis in mice by computed tomography and magnetic resonance imaging

Figure 4

3D-UTE MRI (prospectively gated) of mouse lungs infected with Aspergillus fumigatus. (a) Representative coronal 3D-UTE images of the lungs after intranasal instillation with saline (control, top row) or A. fumigatus FGSC A1258 (infection, bottom row) with manually defined ROI (dashed line) indicated. Black arrows indicate hyperintense spots appearing in the infected lungs. (b) Graph representing the cumulative image score derived from the 3D-UTE images of mice instilled with saline or A. fumigatus spores (ASFU 1731 or FGSC A1258 strain). (c–e) Graphs representing the normalized signal intensity, lung tissue volume and total lung volume quantified from the 3D-UTE lung images. Error bars represent s.d. of multiple mice (saline: n=5, ASFU 1731: n=7–10, FGSC A1258: n=7–8). *P<0.05; **P<0.01; ****P<0.0001.

Back to article page