Figure 5 | Laboratory Investigation

Figure 5

From: Longitudinal, in vivo assessment of invasive pulmonary aspergillosis in mice by computed tomography and magnetic resonance imaging

Figure 5Figure 5

Validation of the imaging results. (a, b) Graphs representing individual galactomannan levels in BAL fluid and the individual fungal loads on day 4 after infection (saline: n=5, ASFU 1731: n=6–7, FGSC A1258: n=5–7). (c) Light microscopic image of a representative PAS-stained lung section 4 days after instillation with FGSC A1258 (Infection (5 × 105 spores), left) or saline (Control, right). Scale bar (upper left corner) measures 50 μm. (d) Light microscopic image of PAS-stained lung section showing fungal hyphae lining the main airways (left image, black arrows) and invading a pulmonary blood vessel (right image, white arrow). Scale bar measures 200 μm. (e) Representative coronal UTE MR images of the lungs 4 days after infection with FGSC A1258. Left hand side (L) and right hand side (R) are indicated on the image. Histological images of the corresponding left lung lobe are next to the corresponding MR image. Scale bars measure 2 mm. ***P<0.001.

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