Figure 6
CT and MR lung imaging of mice infected with a small inoculum (2 × 105 conidia; FGSC A1258 strain). Graphs representing the cumulative image score (A), normalized signal intensity (B), lung tissue volume (C) and total lung volume (D) quantified for individual animals from the 3D-UTE MR images (a), 3D-FLASH MR images (b) and CT images (c). The animals that developed more severe infection were assigned to subgroup A; the animals that developed less severe infection were assigned to subgroup B. Note that the last CT data point of two animals from subgroup A and two animals from subgroup B are missing as these animals were only scanned by MRI at the last time point owing to acute worsening of their general state following anesthesia. (d) Light microscopic image of a PAS-stained lung section from subgroup A (left) and subgroup B (right). Scale bar measures 2 mm. (e, f) Graphs representing individual galactomannan levels in BAL fluid (1/1000 dilution) and fungal load. Error bars represent s.d. of subgroup A (n=3) or subgroup B (n=4). *P<0.05; ***P<0.001.
