Figure 1 | Laboratory Investigation

Figure 1

From: Vasopressin regulates the growth of the biliary epithelium in polycystic liver disease

Figure 1

Representative immunohistochemistry for the three AVP receptors: V1a, V1b, and V2 in liver sections from Normal and BDL-1week rats (a), from Normal and BDL-1week mice (b), and from Normal and PLD human samples (c). Bile ducts express V2 subtype of vasopressin receptors in Normal animals and, with higher levels, in the experimental model of BDL, both in mouse and rat. In human samples, V2 is present in normal biliary epithelium and increases during PLD, both in small (diameter <3 mm) and large (diameter >3 mm) cysts. No or very low staining was visible in the immunohistochemistry for V1a and V1b. No staining was visible when primary antibodies were replaced with non-immune serum, original magnification, × 40.

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