Figure 1 | Laboratory Investigation

Figure 1

From: Tenascin-C secreted by transdifferentiated retinal pigment epithelial cells promotes choroidal neovascularization via integrin αV

Figure 1

(a) Representative photographs of triple immunofluorescence staining for tenascin-C, α-SMA, and CD34 in a CNV membrane excised from an AMD patient. Tenascin-C staining was observed in α-SMA- and pan-cytokeratin-positive cells, and around CD34 positive cells. (b) Triple immunofluorescence staining for tenascin-C, pan-cytokeratin, α-SMA, CD31, F4/80, and integrin αV in lesions observed in a wild-type laser-induced CNV model 5 days post-laser treatment. Pan-cytokeratin-positive cells were stained with α-SMA. Tenascin-C co-stains with pan-cytokeratin, α-SMA, CD31, and integrin αV, but not with F4/80. Nuclei are stained blue. Scale bar, 50 μm.

Back to article page