Figure 6 | Laboratory Investigation

Figure 6

From: Tenascin-C secreted by transdifferentiated retinal pigment epithelial cells promotes choroidal neovascularization via integrin αV

Figure 6

Volume of CNV formed after laser photocoagulation in tenascin-C knockout mice and mice treated with tenascin-C siRNA. (a) Analysis of the volume of CNV lesions 7 days after photocoagulation in wild-type and tenascin-C knockout mice (mean±s.e.m.; n=8 eyes per group). (b) Representative projections (green) and 3D images (red) of CNV lesions. Scale bar, 100 μm. (a and b) CNV volume was significantly smaller in the eyes of tenascin-C knockout mice compared with that in wild-type mice. (c) Analysis of the volume of CNV lesions 7 days after vitreous injection of control siRNA or tenascin-C siRNA (mean±s.e.m.; n=8 eyes per group). (d) Representative projections (green) and 3D images (red) of CNV lesions. Scale bar, 100 μm. (c and d) CNV volume was significantly lower in eyes treated with tenascin-C siRNA (10 and 100 nM) compared with that in eyes treated with control siRNA. *P<0.05, **P<0.01, Student’s t test or ANOVA/Dunnett’s test.

Back to article page