Figure 1
From: Regulation of heterotrimeric G-protein signaling by NDPK/NME proteins and caveolins: an update
General role of nucleoside diphosphate kinase (NDPK) transphosphorylase activity in G-protein activation. Locally present NDPKs replenish the GTP required for G-protein activation. In particular, NDPK-B and NDPK-C can form GTP out of ATP and GDP using a high-energy intermediate on His118 of the NDPK.
