Figure 2
From: Regulation of heterotrimeric G-protein signaling by NDPK/NME proteins and caveolins: an update
Regulation of G-protein activation by nucleoside diphosphate kinases (NDPKs). NDPKs can directly activate G-proteins through a G-protein-coupled receptor (GPCR)-independent pathway involving GTP formation from intermediate phosphorylation of His266 on the Gβ subunit, which results from high-energy phosphate transfer from His118 of the NDPKs (#1). In addition, NDPKs can act as a scaffold, increasing the G-protein membrane content (#2), which is also expected to enhance G-protein signaling.
