Figure 1 | Laboratory Investigation

Figure 1

From: NDPKA is not just a metastasis suppressor – be aware of its metastasis-promoting role in neuroblastoma

Figure 1

A current understanding of NDPK-A in promoting neuroblastoma metastasis. NDPK-A is encoded by the nm23-H1 gene. Overexpression or S120G mutation of NDPK-A found in patients with advanced neuroblastoma promotes neuroblastoma metastasis by inhibiting neuronal differentiation, enhancing migration/extravasation, and increasing survival/colonization of neuroblastoma cells in vitro and in vivo. NDPK-A promotes neuroblastoma metastasis likely via its interacting proteins such as Tiam1, and/or its transcriptional targets such as c-Myc, in addition to other yet-to-be-determined molecular mechanisms.

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