Figure 5 | Laboratory Investigation

Figure 5

From: Iron suppresses erythropoietin expression via oxidative stress-dependent hypoxia-inducible factor-2 alpha inactivation

Figure 5

(a) Changes in VEGF,PHD3,and PGK1 mRNA expression in the kidney of vehicle- or SFO-treated mice. The values are expressed as means±s.d. *P<0.05, **P<0.01 vs vehicle; n=11–13 in each group. (b) The effect of SFO on VEGF,PHD3,and PGK1 mRNA expression in HepG2 cells. The values are expressed as means±s.d. *P<0.05 vs vehicle; n=4 in each group. Effects of SFO on (c) EPO and (d) HIFs in mice with phlebotomy-induced anemia. The values are expressed as means±s.d. *P<0.05, **P<0.01 vs vehicle; n=7 in each group.

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