Table 2 Univariable Cox regression analysis for factors predictive of metastasis
From: The biological and prognostic significance of angiotropism in uveal melanoma
Prognostic factor | n=89 | Metastatic events | Five-year survival rate±s.d. | HR | P-value |
|---|---|---|---|---|---|
Age, years | |||||
<60 | 36 | 22 | 0.620±0.083 | 1 | |
≥60 | 53 | 31 | 0.406±0.075 | 1.43 (0.82–2.48) | NS |
Gender | |||||
Men | 38 | 23 | 0.432±0.085 | 1 | |
Women | 51 | 30 | 0.550±0.075 | 0.87 (0.51–1.51) | NS |
Tumor diameter | |||||
≤15 mm | 18 | 8 | 0.687±0.117 | 1 | |
>15 mm | 71 | 45 | 0.449±0.064 | 1.84 (0.87–3.92) | NS |
Tumor thickness (1 md) | |||||
≤10 mm | 22 | 15 | 0.394±0.107 | 1 | |
>10 mm | 66 | 38 | 0.529±0.067 | 0.7287 (0.40–1.334) | NS |
Extraocular extension | |||||
No | 82 | 46 | 0.517±0.060 | 1 | |
Yes | 7 | 7 | 0.286±0.171 | 3.028 (1.431–7.181) | <0.01 |
Angiotropism | |||||
No | 50 | 21 | 0.684±0.070 | 1 | |
Yes | 39 | 32 | 0.261±0.077 | 3.654 (2.63–9.095) | <0.0001 |
Melanoma cell type | |||||
Spindle | 24 | 9 | 0.848±0.081 | 1 | |
Epithelioid—mixed | 65 | 44 | 0.373±0.064 | 2.663 (1.295–5.472) | <0.01 |
Location (1 md) | |||||
Absence of ciliary body involvement | 77 | 46 | 0.516±0.061 | 1 | |
Presence of ciliary body involvement | 11 | 7 | 0.364±0.145 | 0.99 (0.447–2.22) | NS |
Genomic data | |||||
BAP1 mutation (14 md) | |||||
Absent (non) | 36 | 13 | 0.738±0.080 | 1 | |
Present (yes) | 39 | 31 | 0.360±0.080 | 2.864 (1.494–5.49) | 0.0015 |
Monosomy 3 (7 md) | |||||
Absent | 25 | 7 | 0.764±0.093 | 1 | |
Present | 57 | 44 | 0.373±0.068 | 3.72 (1.67–8.29) | 0.0013 |
