Table 3 Univariable Cox regression analysis for factors predictive of death
From: The biological and prognostic significance of angiotropism in uveal melanoma
Prognostic factor | n=89 | Death events | Five-year survival rate±s.d. | HR | P-value |
|---|---|---|---|---|---|
Age, years | |||||
<60 | 36 | 17 | 0.60±0.083 | 1 | |
≥60 | 53 | 31 | 0.42±0.073 | 1.73 (0.95–3.14) | 0.07 |
Gender | |||||
Men | 38 | 23 | 0.41±0.083 | 1 | |
Women | 51 | 25 | 0.56±0.073 | 0.72 (0.41–1.27) | NS |
Tumor diameter | |||||
≤15 mm | 18 | 6 | 0.70±0.115 | 1 | |
>15 mm | 71 | 42 | 0.45±0.0617 | 2.17 (0.92–5.10) | 0.08 |
Tumor thickness(1 md) | |||||
≤10 mm | 22 | 12 | 0.44±0.108 | 1 | |
>10 mm | 66 | 36 | 0.508±0.065 | 0.938 (0.49–1.81) | NS |
Extraocular extension | |||||
No | 82 | 41 | 0.514±0.0582 | 1 | |
Yes | 7 | 7 | 0.286±0.171 | 2.876 (1.285–6.439) | 0.01 |
Angiotropism | |||||
No | 50 | 15 | 0.717±0.067 | 1 | |
Yes | 39 | 33 | 0.230±0.070 | 4.89 (2.63–9.095) | <0.0001 |
Melanoma cell type | |||||
Spindle | 24 | 7 | 0.80 6±0.087 | 1 | |
Epithelioid—mixed | 65 | 41 | 0.385±0.063 | 3.071 (1.373–6.868) | <0.01 |
Location (1 md) | |||||
Absence of ciliary body involvement | 77 | 40 | 0.523±0.060 | 1 | |
Presence of ciliary body involvement | 11 | 7 | 0.364±0.145 | 1.268 (0.567–2.833) | NS |
Genomic data | |||||
BAP1 mutation (14 md) | |||||
Absent | 36 | 15 | 0.652±0.082 | 1 | |
Present | 39 | 24 | 0.403±0.083 | 1.861 (0.973–3.562) | 0.06 |
Monosomy 3 (7 md) | |||||
Absent | 25 | 8 | 0.747±0.090 | 1 | |
Present | 57 | 38 | 0.374±0.067 | 2.72 (1.265–5.847) | 0.01 |
