Figure 4
From: APX-115, a first-in-class pan-NADPH oxidase (Nox) inhibitor, protects db/db mice from renal injury
Immunohistochemistry findings of the kidney. (a1–a5) PAS, periodic acid-Schiff stain; (b1–b5) α-SMA, alpha-smooth muscle actin stain; (c1–c5) PAI-1, plasminogen activator inhibitor-1 stain; (d1–d5) TGF-β, transforming growth factor beta-1 stain; (e1–e5) type IV collagen stain; (f1–f5) nephrin stain. 1, db/m control; 2, db/m+APX-115; 3, db/db control; 4, db/db+GKT; 5, db/db+APX-115. Original magnification × 1000.
