Figure 3 | Laboratory Investigation

Figure 3

From: Increased expression of latent TGF-β-binding protein 4 affects the fibrotic process in scleroderma by TGF-β/SMAD signaling

Figure 3

The protein level of LTBP-4 in the plasma was elevated in SSc patients. (a) LTBP-4 level detected by ELISA in plasma samples from patients with SSc, LSc, and healthy controls. (b) LTBP-4 level was elevated in the plasma of SSc patients with esophagus involvement. (c) LTBP-4 level was elevated in the plasma of SSc patients with pulmonary fibrosis. (d–f) No obvious difference was detected in SSc patients with Raynaud’s phenomenon, arthralgia, and heart involvement. Results represent the mean±s.e.m. in each group. ***P<0.0001, **P<0.01, *P<0.05. LTBP-4, latent TGF-β-binding protein 4; LSC, localized scleroderma; SSC, systemic scleroderma.

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