Table 2 Adhesive mediators of Teff cell homing into melanoma and other tumor types
From: T-lymphocyte homing: an underappreciated yet critical hurdle for successful cancer immunotherapy
Teff cell molecule | Tumor molecule | Cancer type | References |
|---|---|---|---|
FTIV, FTVII | Melanoma (B16-OVA) | ||
E-selectin, P-selectin | Melanoma (B16-OVA) | ||
E-selectin | Melanoma (patient); TIL binding to HMEC and HUVEC | ||
VLA-4 (α4 subunit) | Melanoma (M05-OVA) | ||
VLA-4 | Melanoma (B16) | ||
VLA-4 (β1 subunit) | Melanoma (patient); TIL binding to HMEC and HUVEC | ||
VLA-4 | Breast cancer (patient); TIL binding to osteoblasts and BMSC | ||
VCAM-1 | Melanoma (M05-OVA) | ||
VCAM-1 | Melanoma (B16) | ||
VCAM-1 | HCC (patient); TIL binding to HCC endothelium | ||
VCAM-1 | Colorectal (patient); TIL binding to purified VCAM-1 | ||
VLA-6 | Melanoma (M05-OVA) | ||
LFA-1 | Melanoma (B16) | ||
LFA-1 (β2 subunit) | Melanoma (patient); TIL binding to HMEC and HUVEC | ||
LFA-1 | Breast cancer (patient); TIL binding to osteoblasts and BMSC | ||
LFA-1 | HCC (patient); TIL binding to HCC endothelium | ||
ICAM-1 | Melanoma (B16) | ||
ICAM-1 | HCC (patient); TIL binding to HCC endothelium | ||
ICAM-1 | Colorectal (patient); TIL binding to purified ICAM-1 | ||
VAP-1 | HCC (patient); TIL binding to HCC endothelium | ||
VAP-1 | SCCHN (patient); TIL binding to SCCHN endothelium | ||
CD44v10 | Melanoma (patient); TIL binding to melanoma cells; TIL migration | ||
uPAR | HCC (patient), CHM (patient); TIL migration | ||
CEACAM-1 | Melanoma (patient); homophilic TIL binding to CEACAM-1 on melanoma cells |
