Figure 2
From: The evolving concept of cancer stem-like cells in thyroid cancer and other solid tumors
Epithelial to mesenchymal transition in primary thyroid tissues and tumors. (a) Normal thyroid showing expression of E-cadherin as membranous staining by immunohistochemistry. (Hematoxylin nuclear stain and diaminobenzidine as chromogen; scale bar, 100 μm). (b) Papillary thyroid carcinoma showing diffuse membranous staining for E-cadherin. (Hematoxylin nuclear stain and diaminobenzidine as chromogen; scale bar, 100 μm). (c) Anaplastic thyroid carcinoma showing loss of E-cadherin in the tumor cells. (Hematoxylin nuclear stain and diaminobenzidine as chromogen; scale bar, 100 μm). (d) Anaplastic thyroid carcinoma showing Slug (Snail 2) expression in the tumor cell nuclei. The normal thyroid and the PTC cells were negative for Slug.35 (Hematoxylin nuclear stain and diaminobenzidine as chromogen; scale bar, 100 μm).
