Figure 1

Quantification of plasma tracer for peritoneal permeability. A calibration curve for the FITC-dextran was prepared by serial dilution of stock (a) (r is greater than 0.97). Increased peritoneal permeability was induced in C57BL/6 mice through chronic exposure to PDF (dialysis group) (b) or by adjuvant-induced peritonitis (inflamed group) (c). After intraperitoneal administration of FITC-dextran solution, blood samples were obtained at different times. The results demonstrate that the peritoneal membrane of the dialysis group is more permeable than that in the control group (b). Compared to the control group, the peritoneal membrane of the inflamed group was shown to be more permeable to FITC-dextran (c). The results are representative of two experiments (n=4 mice per group).