Table 3 Pathological and cytogenetic details of 80 patients with World Health Organization (WHO)-defined ‘myelodysplastic syndrome with isolated del(5q)’

From: WHO-defined ‘myelodysplastic syndrome with isolated del(5q)’ in 88 consecutive patients: survival data, leukemic transformation rates and prevalence of JAK2, MPL and IDH mutations

Pathological and cytogenetic variable

Number a

Dyserythropoiesis (%)

28 (35)

Dysgranulopoiesis (%)

16 (20)

Dysmegakaryopoiesis (%)

69 (86)

Dysplasia affecting a single cell line (%)

36 (45)

Dysplasia affecting two cell lines (%)

27 (34)

Dysplasia affecting all three cell lines (%)

6 (7)

Abnormal metaphases with isolated del(5q) (median, range)

13 (2–26)

5q breakpoints (%)

 5q13q22

2 (2)

 5q13q33

51(57)

 5q15q31

3 (3)

 5q15q33

21 (24)

 5q22q31

4 (5)

 5q22q33

4 (5)

 5q22q35

3 (3)

  1. aPlease note that bone marrow and peripheral smears were available for pathological re-review in 80 patients; cytogenetic information was available for re-review in 88 patients. Seven patients had no overt evidence of myelodysplasia.
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